Oral metronidazole has been noted to potenti-ate the anticoagulant effect of coumarin and warfarin resulting in a prolongation of prothrombin time. The effect of topical metronida-zole on prothrombin time is just not regarded.Other consequences which have been described in association with the use of topical (dermal) formulations of metronidazole i
The incidence of person adverse reactions were not drastically different in between the two regimens. Unless of course percentages are usually stipulated, the incidence of individual adverse reactions listed beneath was fewer than one%:B: May be satisfactory. Possibly animal studies exhibit no chance but human research not readily available or anim
Metronidazole has revealed evidence of mutagenic exercise in several in vitro bacterial assay systems. Additionally, a dose-similar increase in the frequency of micronuclei was noticed in mice after intraperitoneal injections. A rise in chromosomal aberrations in peripheral blood lymphocytes was claimed in patients with Crohn’s illness who h